Research and Science
TruColostrum® is at the forefront of incorporating colostrum into new and innovative applications, guided by the latest research. With an extensive collection of over 5,000 studies shedding light on the science of bovine colostrum, and ongoing research delving into the safest and most advantageous applications for human and animal health, the industry is in a constant state of evolution. Presented below are selected clinical studies that emphasize key benefits contributing to a healthy lifestyle.
Insulin-like Growth Factors (IGF-I & IGF-II)
These growth factors are proteins that play an important role in human growth, both in children and adults.
Epidermal Growth Factor (EGF)
These growth factors aid in cell growth, proliferation, and differentiation. They also aid in repair of damaged tissues.
Transforming Growth Factors (TGF)
These growth factors work together to regulate cell growth in the intestines. They also aid with gastrointestinal repair, bone cartilage formation, and immunity.
Macronutrients and Micronutrients
Crafting Wellness Through the Perfect Blend of Nutrients*
Essential Nutrients
Vitamins
Minerals
& Ions
Carbohydrates
Amino Acids
Proteins
Colostrum Research
Illuminating Paths to Optimal Health
TruColostrum® is complete colostrum in its original form as nature intended. It is the only colostrum on the market that has been tested for ACTIVE antibodies and is never subjected to extractions, conversions, hydrogenations, homogenization, or fractionation. TruColostrum® is minimally processed with unrivaled Advanced Biopotent Technology™.
Azcarate-Peril MA, Ritter AJ, and Savaiano D, et al. Impact of short-chain galactooligosaccharides on the gut microbiome of lactose-intolerant individuals. Proc Natl Acad Sci USA. 2017;114:E367–E375.
Barnard JA, Beauchamp RD, Russell WE, Dubois RN, and Coffey RJ. Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology. 1995;108:564–580.
Belding ME, Klebanoff SJ, and Ray CG. Peroxidase-mediated virucidal systems. Science. 1970;9:195–196.
Border WA and Noble NA. Targeting TGF-β for treatment of disease. Nat Med. 1995;1:1000–1001.
Coffey RJ, Romano M, and Goldenring J. Roles for transforming growth factor-alpha in the stomach. J Clin Gastroenterol. 1995;21(Suppl 1):S36-S39.
Cohen MS, Mao J, Rasmussen GT, Serody JS, and Britigan BE. Interaction of lactoferrin and lipopolysaccharide (LPS): effects of the antioxidant property of lactoferrin and the ability of LPS to prime human neutrophils for enhanced superoxide formation. J Infect Dis. 1992;166:1375–1378.
CR Baumrucker and Blum JW. (1993) Secretion of insulin-like growth factors in milk and their effects on the neonate. Livest Prod Sci. 1993;35: 49–72.
Francis GL, Upton FM, Ballard FJ, McNeil KA, and Wallace JC. Insulin-like growth factors 1 and 2 in bovine colostrum. Biochem J. 1988;251: 95–103.
Gopal PK and Gill HS. Oligosaccharides and glycoconjugates in bovine milk and colostrum. Br J Nutr. 2000;84 Suppl 1:S69–S74.
Hagiwara K, Kataoka S, Yamanaka H, Kirisawa R, and Iwai H. Detection of cytokines in bovine colostrum. Vet Immunol Immunopathol. 2000;76:183–190.
Harmsen MC, Swart PJ, de Béthune MP, et al. Antiviral effects of plasma and milk proteins: Lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. J Infect Dis. 1995;172:380–388.
Jaeger LA, Lamar CH, Cline TR, and Cardona CJ. Effect of orally administered epidermal growth factor on the jejunal mucosa of weaned piglets. Am J Vet Res. 1990;51:471–474.
Kingsnorth AN, Vowles R, and Nash JR. Epidermal growth factor increases tensile strength in intestinal wounds in pigs. Br J Surg. 1990;77:409–412.
Korhonen TK, Valtonen MV, and Parkkinen J, et al. Serotypes, hemolysin production, and receptor recognition of Escherichia coli strains associated with neonatal sepsis and meningitis. Infect Immun. 1985;48:486–491.
Kussendrager KD and van Hooijdonk ACM. Lactoperoxidase: physic-chemical properties, occurrence, mechanism of action and applications. Brit J Nutr. 2000;84:19–25.
Lassiter MO, Newsome AL, Sams LD, and Arnold RR. Characterization of lactoferrin interaction with Streptococcus mutans. J Dent Res. 1987;66:480–485.
Marcotty C, Frankenne F, Van Beeumen J, Maghuin-Rogister G, and Hennen G. Insulin-like growth factor (IGF-1) from cow colostrum: Purification and characterization. Growth Regul. 1991;1:56–61.
Okuyama H, Urao M, Lee D, Drongowski RA, and Coran AG. The effect of epidermal growth factor on bacterial translocation in newborn rabbits. J Pediatr Surg. 1998;33:225–228.
Pakkanen R and Aalto J. Growth factors and antimicrobial factors of bovine colostrum. Int Dairy J. 1997;7:285–297.
Parkkinen J and Finne J. Occurrence of N-acetylglucosamine 6-phosphate in complex carbohydrates. Characterisation of a phosphorylated sialyl oligosaccharide from bovine colostrum. J Biol Chem. 1985;260:1.
Playford RJ. Peptides and gastrointestinal mucosal integrity. Gut. 1995;37: 595–597.
Playford RJ, Weiser MJ. Bovine Colostrum: Its Constituents and Uses. Nutrients. 2021;13(1):265.
Rainard P. Bacteriostatic activity of bovine milk lactoferrin against mastitic bacteria. Vet Microbiol. 1986;11:387–392.
Rawal P, Gupta V, and Thapa BR. Role of colostrum in gastrointestinal infections. Indian J Pediatr. 2008;75: 917–921.
Reiter B. Review of the progress of dairy science: Antimicrobial systems in milk. Journal of Dairy Research. J Dairy Res. 1987;45:131–147.
Simon PM, Goode PL, Mobasseri A, and Zopf D. Inhibition of Helicobacter pylori binding to gastrointestinal epithelial cells by sialic acid-containing oligosaccharides. Infect Immun. 1997;65:750–757.
Thapa BR. Health factors in colostrum. Indian J Pediatr. 2005;72:579–581.
Tripathi V and Vashishtha B. Bioactive compounds of colostrum and its application. Food Res Int. 2006;22:225–244.
Xu RJ, Mellor DJ, Birtles MJ, Breier BH, and Gluckman PD. Effects of oral IGF-I or IGF-II on digestive organ growth in newborn piglets. Biol Neonate. 1994;66:280–287.
Xu RJ, Wang F, and Zhang SH. Postnatal adaptation of the gastro-intestinal tract in neonatal pigs: a possible role of milk-borne growth factors. Livest Prod Sci. 2000;66:95–107.
Yamaguchi Y, Semmel M, Stanislawski L, Strosberg AD, and Stanislawski M. Virucidal effects of glucose oxidase and peroxidase or their protein conjugates on human immunodeficiency virus type 1. Antimicrob Agents Chemother. 1993;37:26–31.
How Antibody Levels Vary with Collection Time
TruColostrum® is collected within first 24 hours, preserving high IgG content
Ingredient Statements
Powerful Solutions, Exceptional Results
